Every year, political candidates from the local to state levels  converge on Founders Square to speak during the fair. In 1980 a major party presidential candidate opened his  general election by speaking at the Neshoba County Fair, that candidate was the late Ronald Reagan. Democratic Senator John Glenn campaigned at the fair in 1983. The fair has seen the likes of Michael Dukakis, Sonny Montgomery, Ray Mabus, Phil Bryant and many more. Candidates are given five (5) - ten (10) minutes each to speak, the political arena has grown over the years, with local candidates speaking on Tuesdays and the state candidates on Wednesday and Thursday.

Some cabins, telephone poles and trees are adorned with political signs from both Republican and Democrats.